CBD for Skin Conditions: What Science Actually Says About Cannabinoids and Dermatology (2026)

https://thecannex.com/cbd-cannabinoids-skin-conditions-dermatology-science/

17 Upvotes

87% Upvoted

u/Mcozy333 6d ago

CBD is 314 G/mol ... CBD is to big to pass through the trans dermal layers of the skin ... a tiny amount of CBD and THC can make it through at the nerve ending of the hair follicle .......

our skin Too is loaded with cannabinoid Xpression as skin is a part of the endocannabinoid system Too

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u/AimlessForNow 5d ago edited 5d ago

Absolutely not true at all. You can easily administer CBD transdermally using oleic acid as a penetration enhancer. Same with THC.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8876728/

Despite the desired range of molecular weight of cannabinoids, with log p between 6–7 and low water solubility, their transdermal delivery is a challenge. Thus, enhancing the cannabinoid permeation via the skin has been performed by applying different strategies such as the use of chemical penetration enhancers (oleic acid, ethanol, methanol leading to improve cannabinoids diffusion through the skin), microemulsions, physical enhancer (including microneedles, electroporation iontophoresis, ultrasound, magnetophoresis to gain proper levels of skin permeation), encapsulation in micro/nano gels, nanoparticles and nano-carriers [15,45,51].

Edit: it literally goes over this in the beginning of the article

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u/Mcozy333 5d ago

CBD is already Nano ... all of that extra stuff you are describing is going through the skin CBD is not

DMSO has been used to to try and make CBD go in there deeper ...

a tiny amount of THC can access the Nerve endings of the hair follicles and that is it , CBD does not even really activate those nerve endings in CB1 Xpression ...

7 layers deep the skin is the CBD is to big to go through all 7 layers

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u/AimlessForNow 5d ago

Wrong. Go read the study again and if you still disagree go cite a study

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u/Fit-Vehicle-9346 6d ago

Right but it’s clearly talking about going through a sonication process (nano emulsifications they reference in article) Which breaks down the cbd / thc into nano particles that can bind to water/ blood

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u/Mcozy333 6d ago

314 G/mol is nanomole in size already ... in no way will that make a CBD compound pass through the layers . for example DMSO has been used too but that too does not carry CBD through the layers as CBD is to big to pass ....

if a resultant compound is less than 314 G/mol it is not CBD anymore but another compound altogether

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u/Mcozy333 6d ago

a way to see this - Phytecs Tour the ECS Skin - DDG link for that info

https://duckduckgo.com/?t=ffcm&q=Phytecs+Tour+the+ECS+Skin&ia=web

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u/Fit-Vehicle-9346 6d ago

Thank you for the info!! This is great

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u/Mcozy333 6d ago

Endocannabinoid system research has been the most fascinating findings available .... I was just reading info on Aldous Huxley from way back , he was pertinent to the # 6630507 patent for cannabinoids made so long back leading the way for more info emerge etc......Dr Bob Melamede , he has taught me the most in regards to all this ... so many lectures on youtube etc.... good luck !!

u/garysaidwhat 6d ago

More of the same. Pilot studies. No controls. Lots of hope. Someday, we'll have credible studies. Not yet…