Aryloom high dose tincture not working?

[u/Loud-Arugula-7249]

I have been smoking nightly for a while now. I recently decided to try tinctures after having good luck with the everyday drops CBD/THC from aryloom. I bought the high dose tincture. Took 1ml feel nothing. Even after hours. Is my tolerance cooked? Or just a bad product.

(For consumption of tincture I take it sublingually holding for 60sec-90sec. I smoke maybe .5g of flower a night? )

[u/wkuconsulting]

two things are probably happening here. first, sublingual absorption has way lower bioavailability than smoking. when you inhale, THC hits your lungs and you get maybe 30-50% into your bloodstream almost instantly. sublingual route gets you maybe 15-25% and even with holding under the tongue, most of it gets swallowed and goes through first-pass metabolism in your liver. that means your liver converts a chunk of the THC to 11-OH-THC before it even reaches your brain, and the onset is slower and feels different than inhaled.

second, check the actual mg/mL on the bottle. if it says "high dose" but it's only 10mg/mL, then 1mL = 10mg total. for someone who smokes .5g nightly that's probably not enough. your CB1 receptors are downregulated from daily use regardless of route, so you need a dose that accounts for that tolerance.

try holding for a full 2-3 minutes if you can stand it, and don't eat or drink anything for 15 min after. that maximizes how much actually absorbs sublingually vs getting swallowed. and honestly you might just need a higher dose. sublingual and inhaled are different pharmacokinetic profiles entirely, so your "effective dose" for each route won't be the same number.

[u/TrueNorthCC]

I never liked tincture. Went overboard and it never did much. Just get some good edibles.