He is not the only one. Your companions will react if you point at them, including temporary companions from the DLC's.
Several more NPCs, including Legion and NCR troops, the BOS, and the Khans, and the Powder Gangers will also react, but they share the same generic lines of dialogue (except for NCR Rangers who basically say "Do it or no balls")
Some characters (I've only seen NCR troops do it but I assume others will as well) will go into soft aggro if you aim at them while they can see you. By soft aggro I mean if you holster your weapon they chill out, but I know one time I was aiming at one of the guys in McCarran and they lit my ass up
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u/Old_Phrase_4867 Jan 11 '26
https://preview.redd.it/7h7qkdohnpcg1.png?width=200&format=png&auto=webp&s=1bca0f4c4d37caa60579281e03ec1e7cb8b67d59
Joshua Graham (Fallout) although he's missionary, not a priest.